Centro di Riferimento Oncologico (IRCCS CRO AVIANO) - National Cancer Institute

CRO is an Italian public institute founded in 1984 and is committed to pursue excellence in all aspects of clinical oncology and management of health services. CRO is also an excellence in translational and clinical research activity for the advancement of scientific knowledge.

Via Franco Gallini, 2, 33081 Aviano PN, Italia




The effectiveness of many anticancer drugs varies greatly from patient to patient, with risks of incorrect dosages and adverse side effects. The invention provides for the first time an electrochemical method to measure the concentration of the drug Imatinib in patient’s plasma and then to establish the optimal dose, with an on-site test readable in real time.
Imatinib is an anticancer drug used in particular for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. The therapeutic drug monitoring (TDM) greatly improves the effectiveness of the cancer treatment and helps to personalize the doses and to limit side effects. Quick procedures are therefore essential. The patented electrochemical method provides a simple, fast and cost-effective protocol for the measurement of Imatinib concentration through plasma collection; said method is suitable for the manufacturing of a device, that will make the test results readily and easily accessible at the patient’s bed (point-of-care), avoiding long times required by specialized analysis. The method involves the selective extraction of the drug on a liquid-liquid extraction column and a following measurement of its concentration using an electrochemical technique, in particular adsorptive stripping voltammetry.


-Simple protocol to be performed also by non-specialized personnel;
-Rapid and accurate diagnosis on site;
-Minimum amount of plasma required;
-Results in real time;
-Determination of drug concentration and therefore of treatment effectiveness for a timely adjustment of individual dosage.


The proposed device is drug specific.


-Protocol to determine Imatinib concentration in patients’ plasma;
-Suitable for developing a portable device to perform therapeutic Imatinib drug monitoring.


Readiness Level (TRL)

experimental proof of concept
"The prototipe is under development in collaboration with a company specialized in the production of sensors."
(The pie chart refers to the entire portfolio contained in the database of the helpdesk)

Technology Readiness Levels (TRL) are a method of estimating technology maturity of Critical Technology Elements (CTE) of a program during the acquisition process. The use of TRLs enables consistent, uniform, discussions of technical maturity across different types of technology.

Patent Grading Report

Patent Grading Report

The Grading Patents Report evaluates and grades US patents

Sample Buy from Wisdomain


Current status

PCT Application


Available for

We are looking for a financial partner


Gregorio Bonazza, Salvatore Daniele, Federico Polo, Giuseppe Toffoli, Stefano Tartaggia

EU-Japan Centre
European CommissionMeti