DDS with sub-second temporal release profile

TECHNOLOGY DESCRIPTION

In contrast to neuro-transmitters, which are released on sub-second time scales, conventional drugs administered intravenously or orally are released over prolonged periods of time.
In this technology the drug is encapsulated in liposomes with gold nano-shells tethered to them. The liposomes are introduced into the tissue and irradiated by a femtosecond laser releasing the drug. The delivered dose is determined by the laser intensity, and the temporal profile of the drug release by the pulse train characteristics as shown in the figure.

BENEFITS

- Controlled sub-second drug delivery
- Liposomes are not damaged by irradiation

LIMITATIONS

A suitable laser is required to initiate drug release

APPLICATIONS

- Parkinsons disease research
- Cancer treatment
- Endocrine disorders
- Delivery of neurotransmitters, therapeutic agents, cytokines, antibodies, or hormones

MATERIALS