Okinawa Institute of Science and Technology

The Okinawa Institute of Science and Technology is an interdisciplinary graduate school offering a 5-year PhD program in Science. Over half of the faculty and students are recruited from outside Japan, and all education and research is conducted entirely in English.

1919-1 Tancha, Onna, Kunigami District, Okinawa Prefecture 904-0495, Japan

DDS with sub-second temporal release profile

managed by Okinawa Institute of Science and Technology


In contrast to neuro-transmitters, which are released on sub-second time scales, conventional drugs administered intravenously or orally are released over prolonged periods of time.
In this technology the drug is encapsulated in liposomes with gold nano-shells tethered to them. The liposomes are introduced into the tissue and irradiated by a femtosecond laser releasing the drug. The delivered dose is determined by the laser intensity, and the temporal profile of the drug release by the pulse train characteristics as shown in the figure.


- Controlled sub-second drug delivery
- Liposomes are not damaged by irradiation


A suitable laser is required to initiate drug release


- Parkinsons disease research
- Cancer treatment
- Endocrine disorders
- Delivery of neurotransmitters, therapeutic agents, cytokines, antibodies, or hormones


Readiness Level (TRL)

technology validated in lab(The pie chart refers to the entire portfolio contained in the database of the helpdesk)

Technology Readiness Levels (TRL) are a method of estimating technology maturity of Critical Technology Elements (CTE) of a program during the acquisition process. The use of TRLs enables consistent, uniform, discussions of technical maturity across different types of technology.

Patent Grading Report

Patent Grading Report

The Grading Patents Report evaluates and grades US patents

Sample Buy from Wisdomain


Current status

PCT Application


Available for




EU-Japan Centre
European CommissionMeti