Centro de Investigación Biomédica en Red, Bioingeniería, Biomateriales y Nanomedicina

The Biomedical Networking Research Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) is one of the 11 thematic areas of CIBER. CIBER groups some of the main Spanish research groups (more than 400) in biomedicine, located in more than 100 institutions distributed around Spain.

Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0 28029 Madrid

Device and method of continuous insulin infusion dose with a hybrid corrective and predictive PID monitoring

managed by CIBER-BBN


Our innovation:
-New automatic calculation of the insulin infusion doses that would be applied subcutaneously to a person with diabetes, to discharge him/her from the continuous decision making on their disease control and to induce normoglycemia, thus reducing the health complications derived from poor glycemic control.
-Integration of a glucose predictor algorithm to anticipate the insulin administration
-The insulin dose is conditioned by security and correction systems to avoid hypoglycemia and hyperglycemia events.
-A dose quantifier module adapts the calculated insulin doses to the electromechanical infusion device.
-Implementation in a microprocessor-based system with memory or commercial devices (smartphones, tablets, personal computers).


Competitive advantages: Innovative insulin dose calculation, versatile device that can be used in many other fields of medicine, precise drug delivery to improve a physiological dysfunction. It can be also used in the veterinary and industrial sectors.


To be determined during further development


Patient need addressed: Diabetes, Type 1

Readiness Level (TRL)

technology concept formulated(The pie chart refers to the entire portfolio contained in the database of the helpdesk)

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Current status

Spanish patent application P201830247 (March 3, 2018), International patent, PCT, to be applied


Available for

Licensing or Assignment


Agustin Rodriguez, Ma. Elena Hernando, Enrique Gomez, Gema Garcia, Carmen Perez


Case manager: Aida Castellanos Paez

EU-Japan Centre
European CommissionMeti