Centro de Investigación Biomédica en Red, Bioingeniería, Biomateriales y Nanomedicina

The Biomedical Networking Research Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) is one of the 11 thematic areas of CIBER. CIBER groups some of the main Spanish research groups (more than 400) in biomedicine, located in more than 100 institutions distributed around Spain.

Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0 28029 Madrid

Devices and methods for multiplexing liquid in biosensor micro-chambers

managed by CIBER-BBN


Our Innovation:
-New method for supplying a functional liquid to biosensor micro-chambers in biosensor devices for multiple-analyte analysis.
-The amount of functional liquid supplied to each biosensor micro-chamber can be independently controlled and can flood at least one biosensor micro-chamber in a functional time period at an accurate very low flow rate by using the fluidic circuit.
-The flow of the functional liquid is selectively inlaid in the biosensor microchambers by one or more micro-valves controlled by an injection control unit so that the flow in each biosensor micro-chamber can be independently controlled with great accuracy.
-It is possible to multiplex a functional liquid to a plurality of biosensor micro-chambers accordingly to a pulsating flow mode.
-it is possible to supply within a functional time period each biosensor micro-chamber with an identical amount of functional liquid and the biosensor behaves as in the continuous flow mode with very low flow rate.


Competitive advantages: cost-effective device, that provide fast, simultaneous and real-time responses. A great reduction of the total flow of the functional liquid. Sensitive and accurate performance for multiple-analyte analysis that meet clinical requirements.


To be determined during further development


Patient need addressed: Multi-analyte detection for specific diseases


Readiness Level (TRL)

experimental proof of concept(The pie chart refers to the entire portfolio contained in the database of the helpdesk)

Technology Readiness Levels (TRL) are a method of estimating technology maturity of Critical Technology Elements (CTE) of a program during the acquisition process. The use of TRLs enables consistent, uniform, discussions of technical maturity across different types of technology.

Patent Grading Report

Patent Grading Report

The Grading Patents Report evaluates and grades US patents

Sample Buy from Wisdomain


Current status

International patent application PCT/EP2018/062230 (May 11, 2018)


Available for

Licensing or Assignment


Giacomo Saviozzi, Juan Pablo Salvador, Manuel Lopez de Miguel, Francisco Palacio, Raquel Pruna, Ma. Pilar Marco, Cecilia Laschi


Case manager: Aida Castellanos Paez

EU-Japan Centre
European CommissionMeti