Okinawa Institute of Science and Technology

The Okinawa Institute of Science and Technology is an interdisciplinary graduate school offering a 5-year PhD program in Science. Over half of the faculty and students are recruited from outside Japan, and all education and research is conducted entirely in English.

1919-1 Tancha, Onna, Kunigami District, Okinawa Prefecture 904-0495, Japan

Disarming Antibiotic-Resistant Bacteria

managed by Okinawa Institute of Science and Technology


Drug resistant bacteria are increasing because of over dependence on antibiotics. The Type III Secretion System is widely employed by bacteria to inject toxins into the cytosol of host cells. Without the secretion system, many pathogenic bacteria are unable to cause disease. To block the secretion, this technology targets a loop of a protein component of the system. In contrast to antibiotics, this approach targets the bacterial virulence factor without directly killing bacteria, avoiding the strong selective pressures of antibiotics, and thus, strongly reducing bacterial drug resistance formation.


- Potential cure for patients suffering from multidrug-resistant and pan-resistant bacterial infections
- Retard the evolution and reduce the spread of drug resistant genes such as those found in hospital-acquired infections
- Maintain the normal flora of the gut and reduce the risk of colitis caused by microbiota dysbiosis
- Applicable to many pathogenic bacterial species because the targeted protein is a highly conserved component of the secretion system


This technology is applicable to diseases transferred by the Type III Secretion System (T3SS), and is not an effective treatment for Cholera which is transferred by the Type II Secretion System. The majority of bacterial infectious diseases are transferred by the T3SS.


- Antibacterial drug discovery: antivirulence therapy for many Gram-negative bacteria including, Bordetella bronchiseptica (whooping cough), Yersinia (plague), Salmonella (food poisoning and typhoid fever), Shigella (dysentery), Enteropathogenic E. coli (diarrhea), Enterohemorraghic E.coli (bloody diarrhea), and Chlamydia (respiratory, ocular disease)
- Prophylactic applications
-- Prevention of enteric disease outbreaks following flooding
-- Disease prevention in aquaculture and farming of animals and plants


Readiness Level (TRL)

experimental proof of concept
"Screening low-molecular weight compounds which bind to the target loop"
(The pie chart refers to the entire portfolio contained in the database of the helpdesk)

Technology Readiness Levels (TRL) are a method of estimating technology maturity of Critical Technology Elements (CTE) of a program during the acquisition process. The use of TRLs enables consistent, uniform, discussions of technical maturity across different types of technology.

Patent Grading Report

Patent Grading Report

The Grading Patents Report evaluates and grades US patents

Sample Buy from Wisdomain


Current status

PCT Application


Available for

Licensing or Collaboration


Trans-Membrane Trafficking Unit

EU-Japan Centre
European CommissionMeti