Centro de Investigación Biomédica en Red, Bioingeniería, Biomateriales y Nanomedicina

The Biomedical Networking Research Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) is one of the 11 thematic areas of CIBER. CIBER groups some of the main Spanish research groups (more than 400) in biomedicine, located in more than 100 institutions distributed around Spain.

Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0 28029 Madrid
managed by CIBER-BBN


Our innovation:
Innovative method for the synthesis and encapsulation in an all-in-one process of a functional version of enzymes with high biological (i.e. enzymatic) activity, vehiculized in EVs for protein based therapies.
The nanodelivery system and the therapeutic compound are produced and isolated at the same time in a simpler process than conventional protein purification processes.
The method produces a mixture comprising proteins with a therapeutic interest and EVs or fragments of lipid bilayer of these EVs, both EVs and proteins obtained from the same cell.
In the case of lysosomal enzymes our system increases the catalytic activity of the enzyme with respect to the naked enzyme produced in the same cell, fact that translates into a much higher biological activity in preclinical disease models.


Competitive advantages: Increase of the treatment efficacy while reducing the production cost. Potential transference of this system to other LSD such as Sanfilippo, Gaucher, Pompe, Hurler or Hunter, and other protein based therapies. Application to other diseases currently treated with recombinant proteins.


To be determined during further development.


Patient need addressed: Lysosomal storage diseases (Fabry disease), cancer, infections, immune disorders.

Readiness Level (TRL)

experimental proof of concept(The pie chart refers to the entire portfolio contained in the database of the helpdesk)

Technology Readiness Levels (TRL) are a method of estimating technology maturity of Critical Technology Elements (CTE) of a program during the acquisition process. The use of TRLs enables consistent, uniform, discussions of technical maturity across different types of technology.

Patent Grading Report

Patent Grading Report

The Grading Patents Report evaluates and grades US patents

Sample Buy from Wisdomain


Current status

Priority European patent application filed (January 24, 2019). Suitable for international extension (PCT application)


Available for

Licensing or Assignment


Simo Schwartz, Ibane Abasolo, Joaquim Seras, Jose Luis Corchero


Case manager: Aida Castellanos Paez

EU-Japan Centre
European CommissionMeti