Okinawa Institute of Science and Technology

The Okinawa Institute of Science and Technology is an interdisciplinary graduate school offering a 5-year PhD program in Science. Over half of the faculty and students are recruited from outside Japan, and all education and research is conducted entirely in English.

1919-1 Tancha, Onna, Kunigami District, Okinawa Prefecture 904-0495, Japan

Synthesis of Novel Pharmaceutical Synthons

managed by Okinawa Institute of Science and Technology


Spirooxindoles are widely found in bioactive molecules and their synthetic intermediates.
This technology provides a facile method to stereo-selectively synthesize novel spirooxindole derivatives from easily accessible starting materials under mild conditions. These novel spirooxindole derivatives are useful for searching for and developing bioactive/bio-functional molecules.


- Synthesis of novel oxa-spirooxindole derivatives
- Asymmetric synthesis of spirooxindole derivatives with functional groups
- Transformation of the synthesized spirooxindole derivatives can further provide new products




Pharmaceutical compound synthons
Diagnostic compounds
Probe molecules for investigating bio-functions


Readiness Level (TRL)

technology validated in lab
"Compound samples for bioassay are available on negotiation"
(The pie chart refers to the entire portfolio contained in the database of the helpdesk)

Technology Readiness Levels (TRL) are a method of estimating technology maturity of Critical Technology Elements (CTE) of a program during the acquisition process. The use of TRLs enables consistent, uniform, discussions of technical maturity across different types of technology.

Patent Grading Report

Patent Grading Report

The Grading Patents Report evaluates and grades US patents

Sample Buy from Wisdomain


Current status

Patented in multiple jurisdictions


Available for



Chemistry and Chemical Bioengineering Unit

EU-Japan Centre
European CommissionMeti