Centro de Investigación Biomédica en Red, Bioingeniería, Biomateriales y Nanomedicina

The Biomedical Networking Research Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) is one of the 11 thematic areas of CIBER. CIBER groups some of the main Spanish research groups (more than 400) in biomedicine, located in more than 100 institutions distributed around Spain.

Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0 28029 Madrid

Use of boron and its derivatives for the treatment of muscular dystrophies

managed by CIBER-BBN

TECHNOLOGY DESCRIPTION

Our innovation:
New treatment for muscular dystrophies based on the administration of boron or a compound of boron.
The active compound can be also used in combination with another active principle or with another current therapy (“Combination therapy”).
The active compound may be administered with an excipient, carrier, and vehicle, commonly used in the pharmacology field, including biodegradable polymeric materials.
The pharmaceutical composition may be administered orally, parenterally, by inhalation spray, or rectally.
In vitro cellular studies presented similar positive results after addition of boron compound in two different muscular dystrophies, with extremely diverse aetiological origin (DMD and DM1).
In vivo studies showed the repair of muscle atrophy to physiologically healthy levels and also an extension of the life expectancy.

BENEFITS

Competitive advantages: The active compound occurs naturally as a mineral o can be prepared easily.
The therapeutic effects of boron are expandable and embracing several muscular dystrophies. Boron treatment cannot only allow muscle regeneration at the anatomical level but also at a functional level.

LIMITATIONS

To be determined

APPLICATIONS

Patient need addressed: muscular dystrophies

Readiness Level (TRL)

3
experimental proof of concept(The pie chart refers to the entire portfolio contained in the database of the helpdesk)

Technology Readiness Levels (TRL) are a method of estimating technology maturity of Critical Technology Elements (CTE) of a program during the acquisition process. The use of TRLs enables consistent, uniform, discussions of technical maturity across different types of technology.

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STATUS

Current status

Spanish patent application P201830905, International patent PCT to be applied

AVAILABILITY

Available for

Licensing or Assignment

INVENTOR / TEAM

Patricia Rico, Manuel Salmerón, Ruben Artero, Ariadna Bargiela, Manuel Perez

GENERAL ENQUIRIES
LICENSING REQUEST

Case manager: Aida Castellanos Paez

EU-Japan Centre
European CommissionMeti