Okinawa Institute of Science and Technology

The Okinawa Institute of Science and Technology is an interdisciplinary graduate school offering a 5-year PhD program in Science. Over half of the faculty and students are recruited from outside Japan, and all education and research is conducted entirely in English.

1919-1 Tancha, Onna, Kunigami District, Okinawa Prefecture 904-0495, Japan

Media Supplement for Giant Synapse Culture

managed by Okinawa Institute of Science and Technology


Generally synapses are small limiting experiments both which can be performed on them and those experiments to short term experiments conducted on large numbers of synapses rather than individual synapses.
The media supplement of this technology makes it possible to culture a synapse of the central nervous system, the calyx of Held developed with vivo-like morphological and physiological properties. The giant synapse is large enough to allow experiments, which would not otherwise be performed. This offers an ideal model for the identification of new signalling pathways in synapse regulation and development and the identification of novel drug targets for neurological disorders.


- Long-term experiments: up to 30 days c.f. 1 day for brain slice culture
- Efficient in-vitro drug screening
- Access to a single synapse: volume is 2,000 greater than conventional synapses




Model for identification of new neural signalling pathways
Identification of novel neural drug targets


Readiness Level (TRL)

technology validated in lab(The pie chart refers to the entire portfolio contained in the database of the helpdesk)

Technology Readiness Levels (TRL) are a method of estimating technology maturity of Critical Technology Elements (CTE) of a program during the acquisition process. The use of TRLs enables consistent, uniform, discussions of technical maturity across different types of technology.

Patent Grading Report

Patent Grading Report

The Grading Patents Report evaluates and grades US patents

Sample Buy from Wisdomain


Current status

National Phase for several jursidictions


Available for



Cellular and Molecular Synaptic Function Unit

EU-Japan Centre
European CommissionMeti